Revolutionary blood test for early Alzheimer’s detection in the works

The data, obtained in collaboration with the University of Bristol and l’Institut de Physique du Globe de Paris (France), analysed brain samples from genetically modified miniature pigs, one of the best physiological matches for research on human diseases.

“We looked at potassium isotopes in the various brain regions in an animal showing preliminary signs of AD and compared this with results from one that did not. What we found was quite striking.” Dr Mahan said.

“We’ve shown that where evidence of accumulation of amyloid beta protein material is present, brain regions show a depletion in potassium and anomalies in its isotopes.

“Factoring in previous studies and based on these new observations, we have hypothesised that the potassium isotopes disappearing from the brain are likely to reappear in the bloodstream.”

Dr Mahan said the findings were critical and very promising with regard to the development of a non-invasive blood test that could potentially determine if a person has Alzheimer’s Disease by comparing their potassium isotope levels to blood samples from individuals unaffected by the disease.

“If you can develop an early diagnostic tool, especially one that is not invasive, then you can slow down  (or maybe even halt) the progression of Alzheimer’s. And that’s where isotope research is really powerful because those isotopic changes are happening more or less instantaneously,” he said.

“Because of that, it is likely this could be detected much earlier than, for example, doing a positron emission tomography (PET) scan, by which time a patient could potentially be decades into the progression of the disease.

“With currently no cure, the best way to minimise the effects of Alzheimer’s Disease is to detect it as early as possible so a patient can take steps to slow the progression of the disease.”

Dr Mahan said his team would soon begin testing human blood samples for potassium isotope levels provided by one of Australia’s largest human sample biobanks.

“We’ll be exploring not only potassium isotope levels, but also copper and zinc and anything we can extract out of those samples in terms of metals and their isotopes, and then we will compare these results with the rich and layered cognitive and blood data available for these samples through the biobank,” he said.

The study was conducted in partnership between JCU’s IsoTropics Geochemistry Lab, Macquarie University, the University of Bristol, Johannes Gutenberg University, Aarhus University, the University of Copenhagen and the University of Paris.

Media release from James Cook University. Note: Content has been edited for style and length.