Scientists have identified 38 specific genetic variants linked to “Intrinsic Capacity” (IC), a key measure of healthy ageing, in a new study from the University of Adelaide. The research provides a new understanding of the biological factors that help some people maintain physical and mental function as they age.
The study analysed genetic data from over 57,000 people and found that genetic factors account for about 20 to 25 per cent of the variability in an individual’s healthy ageing, with the rest influenced by environment and lifestyle.
Intrinsic Capacity, a concept introduced by the World Health Organization (WHO), represents a person’s physical and mental attributes across domains like cognition, vitality, and sensory function.
“Our study is the first of its kind to explore the genetic architecture of IC,” said Associate Professor Azmeraw Amare, the study’s senior author. “These findings provide a foundational understanding of the biological mechanisms that support healthy ageing.”
Amare explained that this new knowledge is the first step toward new medical approaches: “By identifying the genetic factors that influence intrinsic capacity, we can begin to develop targeted interventions to help people maintain their functional abilities as they age.”
The study, published in the Journal of Gerontology: Biological Sciences, found the identified genes are linked to critical bodily processes.
“The identified genes are involved in critical biological processes relevant to healthy ageing process such as metabolism, immune function, neurodegeneration, and cellular ageing,” said first author Melkamu Beyene. “These genes are highly expressed in the brain, heart, muscle, and body tissue.”
Researchers involved in the study said this genetic insight moves the concept of healthy ageing from a simple observation to a target for medical science.
“This research opens the door to personalised approaches for promoting healthy ageing,” said Professor Renuka Visvanathan, a senior author on the paper. “These insights could help clinicians better predict and support healthy ageing trajectories.”
Professor John Beard of Columbia University, who was also involved, said the findings provide the scientific backing needed to turn policy into practice. “This study provides the biological foundation needed to translate that vision into action,” he said.
Ritchelle is a Content Producer for Healthcare Channel, Australia’s premier resource of information for healthcare.
